ABO Blood Group - Medical Genetics Summaries - NCBI Bookshelf

ABO antibodies. The ABO system is the only blood group system in which individuals generate antibodies to antigens absent from their erythrocytes without prior exposure to those antigens. Other blood group systems require exposure, such as through transfusion of blood products, or in pregnancy.

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Objective: To determine the spectrum of phenotypes linked to the ABO blood group system, using genetic determinants of the ABO blood group system. Approach and Results: We assessed the risk of 41 health and disease outcomes, and 36 linear traits associated with the ABO blood group system in the UK Biobank cohort. A total of 406 755 unrelated individuals were included in this study. Blood ...

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However, rare cases of ABO incompatibility have been reported in group A2 mothers with high titer anti B. Hemolytic disease of the newborn due to ABO incompatibility may also be seen in Rh (D) negative women. We encountered two infants (blood group B negative and A positive) with ABO hemolytic disease, born to group O Rh (D) negative mothers.

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