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Enzyme Inhibitors: The Best Strategy to Tackle Superbug NDM-1 ... - MDPI

The GPBA (TGR5) receptor plays crucial roles in various physiological processes, including metabolic regulation and immune responses. The V88L mutation, involving the substitution of valine with leucine at position 88, can impact the receptor's structure, ligand binding, and signaling functions.

Deciphering the Role of V88L Substitution in NDM-24 ... - ResearchGate

NDM variants containing the V88L substitution of NDM-5, -16, -17, -21, and -24 have been reported to show higher carbapenem activity than that of NDM-1, while NDM-20 decreased the activity of carbapenems.

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Figure 1 from Deciphering the Role of V88L ... - Semantic Scholar

This study characterizes the role of the V88L substitution in NDM-24 and provides insight about the NDM variants evolution. Keywords: New Delhi metallo-β-lactamase; NDM-24; kinetic profile ...

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The NDM-5 variants were found harbouring V88L and M154L mutations. The NDM variants were found harboring other antibiotic resistance markers, plasmid replicons and virulence genes. It is essential to resolve the genetic insights of the evolving NDM variants for infection control and correct therapeutics

Molecular detection of the New Delhi metallo-β-lactamase clinical ...

In the process of NDM evolution under an environmental pressure selection, V88L/M154L combination appears to be favorable (Bahr et al., 2017).