v88L alternatif - Deciphering the Role of V88L Substitution in NDM-24 Metallo-β ... - MDPI cv777

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PDF Deciphering the Role of V88L Substitution in NDM-

The role of the V88L substitution in NDM-24 is characterized and insight about the NDM variants evolution is provided and it is shown that V 88L increased the enzyme activity and decreases the protein stability.

Deciphering the Role of V88L Substitution in NDM-24 Metallo-β ... - MDPI

Compared with NDM-5 (V88L and M154L), NDM-20 (V88L, M154L, and R270H) improves the hydrolysis activity of some penicillins and cephalosporins but inhibits the activity of carbapenems, which may...

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... NDM variants containing the V88L substitution of NDM-5, -16, -17, -21, and -24 have been reported to show higher carbapenem activity than that of NDM-1, while NDM-20 decreased the activity of...

CellOnco™ CHO-K1-Tg(Human GPBA Receptor V88L ... - Creative Biolabs

The main goal of the study was to evaluate the role of the V88L substitution in the NDM-24 enzyme. The NDM-24 was generated in the laboratory by a site-directed mutagenesis of NDM-1 and the enzyme properties, protein structure, and thermal stability were studied compared with NDM-1 and NDM-5.

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