neostatin
Corneal transparency: Genesis, maintenance and dysfunction
53 Conversely, neostatin-7 and collagen XVIII were shown to possess anti-lymphangiogenic activities by reducing bFGF-induced corneal lymphangiogenesis. 54 PD-L1 has been shown to act as an anti-angiogenic molecule in the cornea.
Neostatin-7 regulates bFGF-induced corneal lymphangiogenesis
Neostatins are MMP-derived cleavage products of collagen-XVIII. Neostatin-7 is a C-terminal 28 kDa endostatin-spanning fragment generated from collagen-XVIII by MMP-7 . MMP-14 (also known as MT1-MMP) generates 23 kDa neostatin-14 from collagen-XVIII . Murine neostatin-7 inhibits calf pulmonary artery EC proliferation.
Neostatin-7 regulates bFGF-induced corneal lymphangiogenesis. - Europe PMC
In previous studies we showed that neostatin-7, the C-terminal 28kDa endostatin-spanning proteolytic fragment, is generated from the proteolytic action of matrix metalloproteinase matrilysin (MMP)-7 on type XVIII collagen.
Functional characterization of neostatins, the MMP-derived, enzymatic ...
neostatin (plural neostatins) (biochemistry) A fragment of a fibulin which inhibits endothelial cell proliferation.
Nystatin - Wikipedia
Method: GPs (n = 450) and internists (n = 450) were posted a vignette presenting a high-risk patient and a novel drug, 'neostatin'. The benefit was described in terms of NNT or mean gain in disease-free survival.
Therapeutic decisions by number needed to treat and survival gains: a ...
Despite the many pro-lymphangiogenic factors there are relatively few known anti-lymphangiogenic factors. It was recently discovered that neostatin-7, the C-terminal 28 kDa endostatin-spanning proteolytic fragment of collagen XVIII, has anti-lymphangiogenic properties [28,36,106].